Mechanisms of Morphogenesis

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Germ band retraction in Drosophila: a new system to study cell-matrix adhesion? F.B. Schöck¹, N. Perrimon^1,2. 1) Dept. Genetics, Harvard Medical School, Boston, MA, 02115; 2) HHMI, HMS, Boston, MA, 02115. (617) 432-7571.

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Rho1 is involved in multiple morphogenetic processes during Drosophila development. C.R. Magie, S.M. Parkhurst. Division Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109. (206) 667-6489.

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Completion of dorsal closure in Drosophila embryos requires function of the microtubule cytoskeleton. W.L. Rickoll¹, L. Keller², D.P. Kiehart³. 1) Department of Biology, University of Puget Sound, Tacoma, WA 98416; 2) Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., A1-162, Seattle, WA 98109; 3) Department of Biology, Duke University, Durham, NC 27708. (253) 879-3120.

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Epithelial morphogenesis and repair in the fly embryo. P. Martin. Dept. of Anatomy and Developmental Biology, University College London, London, N1 OHW, UK. +020 7679 3362

 Signaling in the Eye

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Signaling and transcription in Cell fate specification in the eye. Raghavendra Nagaraj, Leo Tsuda, Gail Flores, Hua-Jun Yan, Jude Canon, S. Lawrence Zipursky, Utpal Banerjee. University of California, Los Angeles.

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Integration of signals at the prospero enhancer generate specificity to gene expression in the eye disc. Richard Carthew. Northwestern University, IL.

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Genetic control of dorsoventral domain-specific growth of eye disc. Kwang-W. Choi. Baylor College of Medicine, Houston, TX.

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A cell communication pathway for patterning the Drosophila compound eye is regulated by ubiquitin and endocytosis. Janice A. Fischer, The University of Texas, Austin.

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The Drosophila embryonic eye field: Role of Dpp, Hh and EGFR. V. Hartenstein, T. Chang, K. Dumstrei, F. Wang, University of California, Los Angeles.

 Wolbachia

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Host genetic effects on Wolbachia distribution and proliferation during spermatogenesis in Drosophila. M. Clark, T. Karr. Department of Organismal Biology & Anatomy, University of Chicago, IL.

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Wolbachia infection restores oogenesis to female-sterile Sex-lethal alleles. D.J. Starr, T.W. Cline. Molecular and Cell Biology, University of California, Berkeley.

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From parasite to mutualist: Wolbachia infections that increase longevity and egg production in D. melanogaster. A. Fry, M. Palmer, D. Rand. Department of Ecology and Evolutionary Biology, Brown University, Providence, RI.

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Parthenogenesis inducing Wolbachia. Richard Stouthamer. Department of Entomology, University of California, Riverside.

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In vivo analysis of Wolbachia behavior during Drosophila embryogenesis. Uyen Tram, William Sullivan. Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz.

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Differential regulatory mechanisms for muscle-specific transcription. M. Cervera, J J Arredondo, E. Garcia-Zaragoza, R. Marco-Ferreres, J. A. Mas. Departamento de Bioquímica & Instituto Investigaciones Biomédicas, CSIC, Facultad de Medicina, U.A.M. Arzobispo Morcillo 4, 28029 Madrid, Spain.

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Regulating the expression of Actin 57B, the major embryonic myofibrillar actin. Kathleen K. Kelly, Stryder M. Meadows, Richard M. Cripps. University of New Mexico.

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Thin filaments elongate from their pointed ends during IFM myofibril assembly. Michelle Mardahl-Dumesnil, Velia Fowler. The Scripps Research Institute, La Jolla, CA.

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Alternative N-terminal regions of Drosophila Myosin heavy chain tune cross-bridge kinetics for optimal muscle power output. Douglas M. Swank, Sanford I. Bernstein, David W. Maughan. Department of Biology and Molecular Biology Institute, San Diego State University, CA, and Department of Molecular Physiology and Biophysics, University of Vermont, Burlington.

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The converter domain modulates the kinetic properties of Drosophila myosin. Kimberly Palmiter Littlefield¹, Becky M. Sanchez¹, David M. Warshaw², Sanford I. Bernstein¹. 1) Biology Department and Molecular Biology Institute, San Diego State University, CA; 2)Department of Molecular Physiology and Biophysics, University of Vermont, Burlington.

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Isoforms of Drosophila troponin components at the protein level. R. Marco, J. Mateos, J.M. Ruiz, R. Herranz, C. Diaz, M. Cervera . Departamento de Bioquímica & Instituto de Investigaciones Biomédicas "Alberto Sols", UAM-CSIC, Madrid 28029, Spain.

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Models of familial hypertrophic cardiomyopathies associated with human cardiac myosin binding protein C and cardiac troponin T mutations. Mustapha Mokrane, Michel Semeriva. Laboratoire de Génétique et Physiologie du Développement, Campus de Luminy Case 907 cedex 09, 13288 Marseille, France.

 Cell Cycle Checkpoints

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Analysis of downstream effectors of the meiotic checkpoint induced by mutations in the spindle class of repair enzymes. Uri Abdu¹, Michael Brodsky², Trudi Schüpbach1. 1)HHMI/Dept. Molecular Biology, Princeton University, Princeton NJ 08544; 2)University of Massachusetts Medical Center, Worcester, MA 01605.

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Cell cycle and checkpoints in the preblastoderm embryo. J. Y. Ji and G. Schubiger. Dept. Zoology, Univ Washington, Seattle, WA.

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Regulation of mitosis by Wee1 and Myt1 kinases. D. Price, E. Homola, Z. Jin, and S. D. Campbell, Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada

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A role for Dwee1 in regulating progression through mitosis. Jason Stumpff, Tin Tin Su. University of Colorado, Boulder, CO 80309-0347.

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Distinct cytological and functional consequences of anticancer agents in normal and checkpoint compromised Drosophila. K.R. Yu¹, C. Koyama¹, M.K. Mulligan¹, T. Hsieh², W. Sullivan¹. 1) Sinsheimer Laboratories, Department of Biology, University of California, Santa Cruz, CA.; 2) Department of Biochemistry, Duke University Medical Center, Durham, NC.

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Time-lapse video microscopy of living spermatocytes reveals the requirement of different spindle components and the metaphase checkpoint in Drosophila. E. Rebollo, C. González. Cell Biology and Biophysics, EMBL, Heidelberg, Germany.

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The roles of Fzy/Cdc20 and Fzr/Cdh1 in regulating the destruction of cyclin B in space and time. Jordan Raff, Kim Jeffers, Jun-yong Huang. Wellcome/CRC Institute, Tennis Court Road, Cambridge CB2 1QR, UK.

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The Zw10 and Rough Deal (Rod) proteins form a complex that is necessary for accurate chromosome segregation during mitosis and meiosis. Mike Goldberg, Department of Molecular Biology and Genetics, 425 Biotechnology Building, Cornell University, Ithaca, NY.

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G1-G2 compensation in the wing disc cell cycle. Tania Reis, Bruce Edgar. Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.