|
PLENARY/PLATFORM SESSIONS LISTING
Wednesday, March 4 7:00 PM–9:00 PM
Sheraton/Chicago Center
Opening General Session
Room: Sheraton/Chicago Center
Presentations:
7:00 pm Welcome and Opening Remarks. Lynn Cooley. Yale School of Medicine, New Haven, Connecticut.
7:10 pm Introduction of Larry Sandler Memorial Lecture. John Carlson. Yale University, New Haven, Connecticut.
7:15 pm Larry Sandler Memorial Lecture.
7:45 pm 50th Anniversary Program. Scott Hawley. Stowers Institute, Kansas City, Missouri.
Rick Fehon will introduce host Scott Hawley. Scott will lead an interactive discussion with industry legends Mel Green, Dan Lindsley, Tony Mahowald, Thom Kaufman, Ruth Lehmann and Eric Wieschaus. Celebrate how the spirit of sharing and collaboration established at these meeting 50 years ago, continues to propel ground-breaking science today.
Thursday, March 5 8:30 AM–12:00 NOON
Sheraton/Chicago Center
Plenary Session I
Moderator: Rick Fehon, University of Chicago, Illinois
Room: Sheraton/Chicago Center
Presentations:
8:30 am Image Award Presentation. Ross Cagan. Mount Sinai School of Medicine, New York.
8:35 am Ethomics: Progress Toward an Automated Analysis of Behavior. Michael Dickinson. California Institute of Technology, Pasadena.
9:00 am Shaping the Embryo: Cellular Dynamics in Development. Jennifer Zallen. Sloan-Kettering Institute, New York.
9:30 am Heterochromatin Divergence: A Hidden Cause of Speciation. Daniel Barbash. Cornell University, Ithaca, New York.
10:00 am - Break
10:30 am Integrin Adhesion and Morphogenesis. Nick Brown. University of Cambridge, United Kingdom.
11:00 am Canalization of Gene Expression in the Drosophila Blastoderm. John Reinitz. University at Stony Brook, New York.
11:30 am Cell-Cell Communication and Proliferation Control. Wu-Min Deng. Florida State University, Tallahassee.
Thursday, March 5 4:30 PM–6:30 PM
Sheraton 4/5
Gametogenesis and Organogenesis
Moderator: Celeste Berg, University of Washington, Seattle
Room: Sheraton 4/5
1 - 4:30
asunder is a critical regulator of dynein-dynactin localization during Drosophila spermatogenesis. Michael A. Anderson1, Ethan Lee1, Karen G. Hales2, Tom S. Hays3, Laura A. Lee1. 1) Dept. of Cell and Developmental Biology, Vanderbilt Univ. Medical Center, Nashville, TN; 2) Dept. of Biology, Davidson College, Davidson, NC; 3) Dept. of Genetics, Cell Biology, and Development, Univ. of Minnesota, Minneapolis.
2 - 4:45
Follicle rotation: a novel morphogenetic movement dependent on polarized cell-matrix interactions to control the ellipsoid shape of the Drosophila egg. Saori L. Haigo, David Bilder. Department of Molecular & Cell Biology, University of California, Berkeley.
3 - 5:00
Prostaglandin signaling keeps morphology and developmental timing of gene expression in check during late follicle development. Tina L. Tootle1, Dianne Williams1,2, Anna Allen3, Allan Spradling1,2. 1) Dept Embryology, Carnegie Institution, Baltimore, MD; 2) HHMI; 3) NIDDK, Bethesda, MD.
4 - 5:15
Spliceosomal Sm-proteins specify germ cell fate. Graydon B. Gonsalvez, T. K. Rajendra, Ying Wen, A. Gregory Matera. Dept. of Biology, University of North Carolina, Chapel Hill.
5 - 5:30
Full genome analysis of morphogenesis and function of the Drosophila muscle. Frank Schnorrer1,2, Georg Dietzl2, Cornelia Schönbauer1, Christoph Langer1, Katharina Schernhuber2, Michaela Fellner2, Alexander Stark2, Barry Dickson2. 1) Muscle Dynamics, Max-Planck-Institute of Biochemistry, Munich, Germany; 2) IMP, Vienna, Austria.
6 - 5:45
LRT, a putative tendon-specific modulator of Robo activity in embryonic muscle development. Bess Wayburn, Talila Volk. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.
7 - 6:00
Serrano (Sano) is a novel planar cell polarity regulator that controls tracheal tube length. Se-Yeon Chung1, Melissa Vining1, Pamela Bradley1, Chih-Chiang Chan2, Keith Wharton2, Deborah Andrew1. 1) Dept. of Cell Biology, Johns Hopkins University, Baltimore, MD; 2) Dept. Pathol Mol Biol, University of Texas Southwestern Medical Center, Dallas.
8 - 6:15
The RabGAP Whacked regulates central -versus- peripheral seamless tube growth in tracheal terminal cells. Amin S. Ghabrial. Department of Cell & Developmental Biology, University of Pennsylvania, Philadelphia, PA.
Thursday, March 5 4:30 PM–6:30 PM
Chicago 6/7
Neurophysiology and Behavior
Moderator: Ravi Allada, Northwestern University, Evanston, Illinois
Room: Chicago 6/7
9 - 4:30
Odor coding by the entire repertoire of larval receptors. D. Mathew1, S. A. Kreher1, L. Luo2, S. A. Montague1, J. Kim3, A. D. Samuel2, J. R. Carlson1. 1) Dept MCD-Biology, Yale Univ., New Haven, CT; 2) Dept. of Physics, Harvard Univ., Cambridge, MA; 3) Dept. of Biology, Univ. of Pennsylvania, Philadelphia.
10 - 4:45
Calcium and cAMP dynamics during learning-related signal integration in the mushroom body. Seth M. Tomchik1,3, Ron L. Davis1,2. 1) Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX; 2) Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX; 3) W.M. Keck Center for Interdisciplinary Bioscience Training, Houston, TX.
11 - 5:00
A neural and genetic basis for male sex drive rhythm in Drosophila. Shinsuke Fujii, Hubert Amrein. Molecular Genetics & Microbiol, Duke Univ. Medical Center, Durham, NC.
12 - 5:15
Neurons in the pars intercerebralis regulate circadian rhythm, male courtship behavior, and the timing of social interactions in Drosophila melanogaster . Emma Jane Peebles, Tom Goldman, Dhruv Grover, Simon Tavaré, Michelle Arbeitman. Molecular & Computational Biology, University of Southern California, Los Angeles, CA 90089.
13 - 5:30
takeout family members are required in the blood brain barrier for male courtship. Brigitte Dauwalder, Valbona Hoxha, Nancy Vanaphan, Chamala Lama, Jessica Boldon. Department of Biology and Biochemistry, University of Houston, Houston, TX.
14 - 5:45
Brain dopamine is required for normal behavioral responses to light. J. Hirsh1, T. Riemensperger2, H. Coulom2, M. Iche2, S. Birman2. 1) Dept. of Biology, Univ. of Virginia, Charlottesville; 2) 1Genetics of Neurotransmission, IBDML-Developmental Biology Institute, CNRS-Université de la Méditerranée, Campus de Luminy, Marseille, France.
15 - 6:00
S6 Kinase mediates post mating dietary switch and nutrient balance in Drosophila melanogaster.. Pankaj Kapahi, Miguel Vargas, Ninguang Luo, Atsushi Yamaguchi. Dept. of Biology, Buck Institute, Novato, CA.
16 - 6:15
Cytokine signaling mediates UV-induced pain sensitization in Drosophila larvae. Michael J. Galko1, Daniel T. Babcock1, Christian Landry2. 1) Dept. Biochem/Molec Biol, M. D. Anderson Cancer Center, Houston, TX; 2) Dept Radiation Physics, M. D. Anderson Cancer Center, Houston, TX.
Thursday, March 5 4:30 PM–6:30 PM
Chicago 8-10
Regulation of Gene Expression
Moderator: Steve Crews, University of North Carolina, Chapel Hill
Room: Chicago 8-10
17 - 4:30
Comparison of gene expression at cellular resolution in Drosophila reveals distinct transcriptional niches between species. Angela H. DePace1, Charless C. Fowlkes5, Cris L. Luengo7, Soile V. E. Keränen2, Clara Henriquez2, Lisa Simirenko2,3, Kelly Eckenrode1, Miriah Meyer6, David W. Knowles2, Mark D. Biggin2, Jitendra Malik4, Michael B. Eisen2,3. 1) Systems Biology, Harvard Medical School, Boston, MA; 2) Genome Sciences Department, Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA; 3) Molecular and Cellular Biology, University of California, Berkeley, CA; 4) Department of Computer Science, University of California, Berkeley; 5) Department of Computer Science, University of California, Irvine; 6) Institute for Innovative Computing, Harvard University, Cambridge MA; 7) Centre for Image Analysis, Uppsala University, Sweden.
18 - 4:45
Making random molecular collisions into coordinated gene expression. Alistair Nicol Boettiger1,2, Michael Levine2. 1) Biophysics Grad. Group, Univ. of California; 2) Dept. Mol and Cell Bio, Univ California, Berkeley.
19 - 5:00
A transcriptional regulatory network for retinal differentiation in Drosophila. Stein Aerts, Xiao-Jiang Quan, Annelies Claeys, Jiekun Yan, Bassem Hassan. Molecular and Developmental Genetics, VIB-KULeuven, Leuven, Vl-Brabant, Belgium.
20 - 5:15
Activation of Wingless targets requires bipartite recognition of DNA by TCF. Kenneth M. Cadigan, Mikyung V. Chang, Jinhee L. Chang, Anu Gangopadhyay, Andrew Shearer. Dept Mole. Cell & Dev. Biol, Univ. of Michigan, Ann Arbor.
21 - 5:30
Control of noisy rhodopsin gene expression ensures robustness in the fly eye. Robert J. Johnston1, Yoshiaki Oshiaki2, Hideki Nakagoshi2, Claude Desplan1. 1) Dept Biol, New York Univ, New York, NY; 2) Okayama University, Japan.
22 - 5:45
Genome-Wide Profiling of Yan Reveals Two Distinct Binding Patterns and Suggests Chromatin Spreading as a Mechanism of Target Gene Regulation. Jie Zhang, Maureen Cetera, Pavithra Vivekanand, Ilaria Rebay. Ben May Department for Cancer Research, University of Chicago, Chicago, IL.
23 - 6:00
Nitric oxide, nuclear receptors, and transcriptional regulation: A novel mechanism for E75 based transcriptional redox sensing and its role in Drosophila development. Aleksandar S. Necakov, Lucia Caceres, Henry M. Krause. Terence Donnelly Centre for Cellular and Biomolecular Research, The University of Toronto, Ontario, Canada.
24 - 6:15
microRNA-7 mediates robust developmental processes during environmental fluctuation. Justin J. Cassidy1, Xin Li2, Richard Carthew1. 1) Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL; 2) Department of Biology, New York University, New York.
Friday, March 6 8:30 AM–12:30 PM
Sheraton 4/5
Cell Biology and Cytoskeleton
Moderator: Elizabeth Chen, Johns Hopkins Medical School, Baltimore, Maryland
Room: Sheraton 4/5
25 - 8:30
How do bristles elongate? T. Otani, K. Oshima, M. Takeda, S. Hayashi. Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe, Hyogo, Japan.
26 - 8:45
Wash, a Rho1 effector, links linear and branched nucleation factors. Raymond Liu, Maria Teresa Abreu-Blanco, Kevin Barry, Elena Linardopoulou, Gregory Osborn, Susan Parkhurst. Fred Hutchinson Cancer Research Center, Seattle, WA.
27 - 9:00
PINCH, ILK and RSU1 form a stabilized protein complex required for integrin function in Drosophila. Julie Kadrmas1,2, Maria Elias1,2, Mary C. Beckerle1,2,3. 1) Department of Oncological Sciences, University of Utah, Salt Lake City; 2) Huntsman Cancer Institute, University of Utah, Salt Lake City; 3) Department of Biology, Unversity of Utah, Salt Lake City.
28 - 9:15
Kinesin-II plays an essential role in localization of cell polarity proteins and photoreceptor morphogenesis. Bibhash Mukhopadhyay1, Sang-Chul Nam3, Wonseok Son2, Kwang-Wook Choi1,2. 1) Program in Developmental Biology, Baylor College of Medicine, Houston, TX; 2) Department of Cell Biology, Baylor College of Medicine, Houston, TX; 3) Department of Biology, Baylor University, Waco, TX.
29 - 9:30
A novel role for an APC2-Diaphanous complex in regulating actin organization in Drosophila. Rebecca L. Webb, Meng-Ning Zhou, Megha Kapur, Brooke M. McCartney. Dept. of Biological Sciences, Carnegie Mellon Univ., Pittsburgh, PA.
30 - 9:45
Tumbleweed/RacGAP50C directs perinuclear g-tubulin localization to organize microtubules for myotube extension. Colleen M. Guerin1,2, Sunita G. Kramer1,2. 1) Dept Pathology & Lab Medicine, RWJMS-UMDNJ, Piscataway, NJ; 2) Joint Graduate Program in Cell & Dev Biology, GSBS at RWJMS-UMDNJ and Rutgers, the State University of New Jersey, Piscataway, NJ.
31 - 10:00
Defining the roles of Hazy and Otd in photoreceptor cell morphogenesis. Andrew C. Zelhof, Ashwini Oke, Monalisa Mishra. Biol, Indiana Univ, Bloomington, IN.
10:15 am - Break
32 - 10:45
Sip1, the Drosophila orthologue of EBP50/NHERF1, interacts with the Sterile 20 family kinase Slik to regulate Moesin activity. Sarah Campbell Hughes1, Etienne Formstecher2, Richard G. Fehon3. 1) Department of Medical Genetics, University of Alberta, Edmonton, AB, Canada; 2) Hybrigenics, 3-5 impasse Reille, Paris, France; 3) Department of Molecular Genetics and Cell Biology, University of Chicago, IL.
33 - 11:00
The Hippo pathway regulates apico-basal polarity independently of its growth control function. A. Genevet1, C. Polesello1,2, F. Robertson3, F. Pichaud3, K. Blight4, L. Collinson4, N. Tapon1. 1) Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London, United Kingdom; 2) Centre de Biologie du Développement, UMR5547, CNRS/Université Paul Sabatier Toulouse III, Toulouse, France; 3) MRC Laboratory for Molecular Cell Biology and Cell Biology Unit, Department of Anatomy and Developmental Biology, University College London, London, United Kingdom; 4) Electron Microscopy Unit, Cancer Research UK, London Research Institute, London, United Kingdom.
34 - 11:15
Planar cell polarity and the cytoskeleton: searching for Rho kinase substrates. Andreas Jenny1, Gretchen Dollar1, Hebist Berhane1, Cathie Pfleger2. 1) Dept Molecular & Dev Biol, Albert Einstein Col Medicine, Bronx, NY; 2) Dept. of Oncological Sciences, Mount Sinai School of Medicine, New York, NY.
35 - 11:30
Safeguarding genetic integrity by microtubule-dependent intracellular transport of nuclei. Emmanuel Vanrobays, David Ish-Horowicz. Developmental Genetics Laboratory, Cancer Research UK, LONDON, United Kingdom.
36 - 11:45
Type II phosphatidylinositol 4-kinase is required for glue granule biogenesis in Drosophila. J. Burgess1, M. Jauregui1, P. Leventis1, G. L. Boulianne1, H. Kramer2, J. A. Brill1. 1) Stem Cell & Dev. Biology, Hospital for Sick Children, Toronto, Ontario, Canada; 2) Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas.
37 - 12:00
polished rice that encodes 11 and 32 aa-peptide regulates subnuclear localization and activity of transcription factor Shavenbaby in denticle formation. Takefumi Kondo1,2, Yoshiko Hashimoto1, Yuji Kageyama1,3. 1) National Institute for Basic Biology, Okazaki, Aichi, Japan; 2) JSPS, Japan; 3) PRESTO, JST, Japan.
38 - 12:15
Blown fuse negatively regulates the Wasp-mediated actin polymerization during myoblast fusion through a novel competition mechanism. Peng Jin, Elizabeth Chen. Molecular Biol & Genetics, Johns Hopkins Univ, Baltimore, MD.
Friday, March 6 8:30 AM–12:30 PM
Chicago 6/7
Evolution and Quantitative Genetics
Moderator: Sergey Nuzhdin, University of Southern California, Los Angeles
Room: Chicago 6/7
39 - 8:30
Formation and Longevity of Chimeric and Duplicate Genes in Drosophila melanogaster . Rebekah L. Rogers1, Trevor Bedford1,2, Daniel L. Hartl1. 1) Organismic and Evol. Bio, Harvard University, Cambridge, MA; 2) Department of Ecology and Evolutionary Biology University of Michigan, Ann Arbor, MI.
40 - 8:45
High rate of recent transposable element-induced adaptation in Drosophila melanogaster. Josefa Gonzalez, Kapa Lenkov, Mikhail Lipatov, J. Michael Macpherson, Dmitri Petrov. Department of Biology, Stanford University, Stanford, CA.
41 - 9:00
Knock down of genes recently derived from non-coding DNA affects viability and distorts sex ratio. Josephine Anna Reinhardt, Corbin D. Jones. Biology, Univ North Carolina, Chapel Hill, NC.
42 - 9:15
Horizontal transfer of transposable elements between insect orders. Neil Milan1,2, Todd Schlenke1,2. 1) Population Biology, Ecology, & Evolution Program, Emory Univ., Atlanta, GA; 2) Dept. of Biology, Emory Univ., Atlanta, GA.
43 - 9:30
Population genomic analysis of Drosophila melanogaster using short-read sequencing data. Timothy Sackton1, Rob Kulathinal1, Aaron Quinlin2, Gabor Marth2, Andrew Clark3, Daniel Hartl1. 1) Organismic & Evol Bio, Harvard Univ, Cambridge, MA; 2) Department of Biology, Boston College, Boston MA; 3) Molecular Biology and Genetics, Cornell University, Ithaca NY.
44 - 9:45
The effect of the bab locus on abdominal pigmentation variation. Ryan D. Bickel1,2, Sergey Nuzhdin1, Artyom Kopp2. 1) Molecular & Computational Biology, University of Southern California, Los Angeles, CA; 2) Department of Evolution and Ecology, University of California - Davis, Davis, CA.
45 - 10:00
Evolution of the inverse Dpp and Brk gradient during the development of winged and wingless castes of ants. S. Shbailat, E. Abouheif. Biology, McGill University, Montreal, Quebec, Canada.
10:15 am - Break
46 - 10:45
Dynamic lineage-specific evolution across multiple neuroectodermal enhancers. Albert J. Erives, Justin Crocker, Nathan Potter. Dept Biological Sci, Dartmouth Col, Hanover, NH.
47 - 11:00
Metabolomics of Genotype by Environment Interactions underlying Metabolic Syndrome in Drosophila. Laura K. Reed1, Stephanie N. Williams1, Mastafa Springston1, Julie Brown1, Nigel Deighton2, Norm Glassbrook2, Greg Gibson3. 1) Genetics, NCSU, Raleigh, NC; 2) GSL, NCSU, Raleigh, NC; 3) School of Integrative Biology, U. of Queensland, Brisbane, Australia.
48 - 11:15
A non-functional gustatory receptor is critical to host preference in Drosophila sechellia. Corbin D. Jones. Dept Biol & CCGS, Univ North Carolina, Chapel Hill, NC.
49 - 11:30
Functional Regulatory Divergence of the Innate Immune Response in Interspecific Drosophila Hybrids. Erin Hill-Burns, Andrew Clark. Dept Molecular Biol & Genetics, Cornell Univ, Ithaca, NY.
50 - 11:45
Use of high-density full-genome tiling arrays to identify genomic regions associated with selection for divergent egg size in Drosophila melanogaster. Cecelia M. Miles, Bin He, Martin Kreitman. Dept Ecology & Evolution, Univ Chicago, Chicago, IL.
51 - 12:00
Molecular function of Odysseus, a hybrid male sterility gene, in Drosophila. C.-T. Ting1,4, Y.-J. Cheng2, K.-J. Tan3, P.-C. Lin4, S.-C. Tsaur3. 1) Department of Life Science & Institute of Ecology and Evolutionary Biology, National Taiwan University, Taipei, Taiwan, ROC; 2) Institute of Molecular and Cellular Biology, National Tsing-Hua University, Hsinchu, Taiwan, ROC; 3) Biodiversity Research Center, Academia Sinica, Taipei, Taiwan, ROC; 4) Institute of Zoology, National Taiwan University, Taipei, Taiwan, ROC.
52 - 12:15
A single gene causes both male sterility and segregation distortion in Drosophila hybrids. Nitin Phadnis1,2, Allen Orr2. 1) Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA; 2) Department of Biology, University of Rochester, Rochester, NY.
Friday, March 6 8:30 AM–12:30 PM
Chicago 8-10
Chromatin and Epigenetics
Moderator: Ting Wu, Harvard Medical School, Boston, Massachusetts
Room: Chicago 8-10
53 - 8:30
A sequence motif within chromatin entry sites directs MSL establishment on the Drosophila X chromosome. Artyom A. Alekseyenko1,2, Shouyong Peng1,3, Erica Larschan1,2, Andrey A. Gorchakov1,2, Ok-Kyung Lee1, Peter Kharchenko3, Sean D. McGrath4, Charlotte I. Wang2, Elaine R. Mardis4, Peter J. Park1,3, Mitzi I. Kuroda1,2. 1) Division of Genetics, Dept. of Medicine, HPCGG, BWH, Boston, MA; 2) Department of Genetics, HMS, Boston, MA; 3) Children's Hospital Informatics Program, Children's Hospital, Boston, MA; 4) Department of Genetics and Genome Sequencing Center, Washington University School of Medicine, St. Louis, MO.
54 - 8:45
Verrocchio, an OB-fold domain containing protein, is required for Drosophila telomere protection. L. Ciapponi1, G. D. Raffa1, S. Cugusi1, C. Sorino1, G. Cenci2, M. Gatti1. 1) Sapienza, University of Rome, Dept. Genetics & Molecular Biology, Rome, Italy; 2) University of L'Aquila, DBBA, L'Aquila, Italy.
55 - 9:00
The piRNA pathway is required for telomere protection. Jaspreet S. Khurana, Nadine Schultz, William E. Theurkauf. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester.
56 - 9:15
Using fC31integrase to dissect whole regulatory domains within the BX-C. Francois Karch, Carole Iampietro, Robert K. Maeda, Annick Mutéro, Maheshwar Gummalla, Fabienne Cléard. Dept. Zoology & Animal Biology, University of Geneva, Switzerland.
57 - 9:30
Understanding the role of a Drosophila insulator protein in the female germline. Alexey A. Soshnev1, Ryan M. Baxley1, Pamela K. Geyer1,2. 1) Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA; 2) Department of Biochemistry, University of Iowa, Iowa City, IA.
58 - 9:45
Deficiency Screen For Interacting Genes of Ovarian Tumor. Stephen M. Klusza, Amanda Novak, Wu-Min Deng. Dept Biological Sci, Florida State Univ, Tallahassee, FL.
59 - 10:00
Polycomb-dependent regulatory interactions between distant Hox loci in Drosophila species. Frédéric Bantignies, Virginie Roure, Giacomo Cavalli. Institut de Génétique Humaine, CNRS-UPR 1142, Montpellier, France.
10:15 am - Break
60 - 10:45
Defining the requirements for Polycomb group response elements (PREs) at the engrailed locus. Melissa Cunningham, Judy Kassis. Eunice Kennedy Shriver NICHD, NIH, Bethesda, MD.
61 - 11:00
Condensins reveal a unifying model for the regulation of chromosome pairing in somatic, polytene and meiotic cells. Giovanni Bosco, Tom A. Hartl, Helen F. Smith. Dept Molecular & Cell Biol, Univ Arizona, Tucson, AZ.
62 - 11:15
A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity. Patrizia Morciano1, Chiara Carrisi2, Linda Mannini3, Giosalba Burgio4, Gianluca Cestra5, Giuseppe De Benedetto6, Davide Corona4, Antonio Musio3, Loredana Capobianco2, Giovanni Cenci1. 1) BBA, Università dell'Aquila, Coppito L'Aquila, L'Aquila, Italy; 2) DiSTeBA, Università del Salento, Lecce, Italy; 3) ITB,CNR, Pisa, Italy; 4) DiSBi, DTI, Università di Palermo, Italy; 5) DGBM, Università La Sapienza, Roma, Italy; 6) DBAS, Università del Salento, Italy.
63 - 11:30
Deciphering chromatin regulatory landscape during the life cycle of Drosophila melanogaster. P. K. Shah1, N. Negre1, C. Morrison1, Z. Li2, E. Heinz1, M. Domanus1, B. Ren2, K. P. White1. 1) Institute for Genomics and Systems Biology, The University of Chicago, Cummings Life Sciences Center 400A, 920 East 58th Street, Chicago, IL 60637, USA; 2) Ludwig Institute for Cancer Research, University of California, San Diego, 9500 Gilman Ave., La Jolla, California 92037, USA.
64 - 11:45
De novo monomethylation of histone H4 lysine 20 is essential for proper nucleosome spacing. A. Sakaguchi1, M. Seth-Pasricha1, P. Schedl2, R. Steward1. 1) Waksman Inst, Rutgers Univ, Piscataway, NJ; 2) Dept of Mol Bio, Princeton Univ, Princeton, NJ.
65 - 12:00
Chromatin organization of the dot chromosome in D. melanogaster and D. virilis. N. C. Riddle1, P. Kharchenko3, P. J. Park2,3, S. C. R. Elgin1. 1) Department of Biology, Washington University, St. Louis, MO; 2) Harvard-Partners Center for Genetics and Genomics, Division of Genetics, Department of Medicine, Brigham & Women's Hospital, Boston, MA; 3) Children's Hospital Informatics Program, Children's Hospital, Boston, MA.
66 - 12:15
Genomic Imprinting in Drosophila. Vett K. Lloyd1, Andrew Haigh2, William MacDonald2, Lori McEachern2, Ruth Godoy1. 1) Dept Biol, Mt Allison Univ, Sackville, NB, Canada; 2) Dept. Biology, Dalhousie University, Halifax, NS, Canada.
Friday, March 6 4:30 PM–6:30 PM
Sheraton 4/5
Drosophila Models of Human Diseases
Moderator: Mel Feany, Harvard Medical School, Boston, Massachusetts
Room: Sheraton 4/5
67 - 4:30
The RhoL GTPase is required to modulate Rap1 function and permit the epithelial invasion of immune cells. Daria E. Siekhaus, Martin Haesemeyer, Olivia Moffitt, Ruth Lehmann. Dept Dev Genetics, HHMI, NYUSOM, Skirball Inst, New York, NY.
68 - 4:45
Zfrp8/PDCD2 in fly and human hematopoiesis. Svetlana Minakhina1, Dale Schaar2, Ruth Steward1. 1) Waksman Inst, Rutgers Univ, Piscataway, NJ; 2) Cancer Institute of NJ, UMDNJ, New Brunswick, NJ.
69 - 5:00
The role of molecular chaperones and the UPP in TPIsugarkill protein degradation. Michael Palladino, Jacquelyn Seigle, Alicia Celotto, Stacy Hrizo. Pharmacology & Chem. Bio., Univ. of Pittsburgh, PA.
70 - 5:15
Analysis of Arouser, an adaptor portein that functions to modulate responses to alchol. Mark Eddison1, Douglas Guarnieri2, Che Hsiung Liu3, Kevin Moffat3, Ulrike Heberlein1. 1) Dept. of Anatomy, Univ. of California, San Francisco; 2) Dept. of Psychiatry and Neurobiology, Yale University, New Haven, CT; 3) Dept. of Biological Sciences, University of Warwick, Coventry, UK.
71 - 5:30
A genetic screen for dominant suppressors of pink1. S. Vilain, M. Vos, P. Verstreken. Laboratory of Neuronal Communication VIB, Department of Molecular and Developmental Genetics K.U. Leuven, Center for Human Genetics, Belgium.
72 - 5:45
Inactivation of Drosophila Huntingtin affects long-term adult functioning and the pathogenesis of a Huntington’s disease model. Sheng Zhang1, Mel B. Feany2, Sudipta Saraswati3, J. Troy Littleton3, Norbert Perrimon1,4. 1) Dept Gen, Harvard Med Sch, Boston, MA; 2) Department of Pathology, Brigham and Women’s Hospital 77 Avenue Louis Pasteur Harvard Medical School, Boston, MA 02115; 3) The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences Massachusetts Institute of Technology, Cambridge, MA 02139; 4) Howard Hughes Medical Institute.
73 - 6:00
Using the Drosophila heart to analyze polygenic contributions to congenital heart defects in Down syndrome. Tamar R. Grossman1, Amir Gamliel2, Robert J. Wessells3, Ouarda Taghli-Lamallem4, Kristen Jepsen2, Kirk L. Peterson5, Michael G. Rosenfeld2, Julie R. Korenberg6, Rolf Bodmer4, Ethan Bier1. 1) Sec Cell & Dev Biol, UCSD, La Jolla, CA; 2) HHMI, Dept Med, UCSD , La Jolla, CA; 3) Univ Michigan, Ann Arbor, MI; 4) Burnham Inst, La Jolla, CA; 5) School Med, UCSD, La Jolla, CA; 6) Brain Inst, Univ Utah.
74 - 6:15
SMARCAL1 deficiency: the paradox of phenotypic specificity. M. Morimoto1, C. Myung1, A. Fam1, K. S. Cho2, D. Leung1, K. Choi1, Y. Huang1, C. F. Boerkoel1. 1) Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, Canada; 2) Department of Biological Sciences, Konkuk University, Seoul, Republic of Korea.
Friday, March 6 4:30 PM–6:30 PM
Chicago 6/7
Cell Division and Growth Control
Moderator: Iswar Hariharan, University of California, Berkeley
Room: Chicago 6/7
75 - 4:30
The nuclear spindle matrix complex protein, Chromator, is required for proper microtubule spindle formation and mitosis in Drosophila neuroblasts. Changfu Yao, Y. Ding, U. Rath, L. Zhu, J. Girton, K. M. Johansen, J. Johansen. Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, IA.
76 - 4:45
Heterochromatic threads connect oscillating chromosomes during prometaphase I of Drosophila Oocytes. Stacie E. Hughes1, William D. Gilliland1, Jeffrey L. Cotitta2, Satomi Takeo1, Kim Collins1, R. Scott Hawley1,2. 1) Stowers Inst Medical Research, Kansas City, MO; 2) Department of Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
77 - 5:00
Dilp6, a post-feeding Insulin-like peptide that controls pupal growth. Maija Slaidina, Renald Delanoue, Pierre Leopold. Institute of Developmental Biology and Cancer, University of Nice, CNRS-UMR-6543, Nice, France.
78 - 5:15
Epigentic control of growth by the Drosophila Polycomb gene family. Anne-Kathrin Classen1, Kieran Harvey2, David Bilder1. 1) Department of Molecular and Cell Biology, University of California at Berkeley, CA, USA; 2) Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Australia.
79 - 5:30
The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Caroline Badouel1, Laura Gardano2, Nancy Amin1, Robyn Rosenfeld1, Thierry Le Bihan3, Helen McNeill1. 1) Samuel Lunenfeld Res Inst, Toronto, Ontario, Canada; 2) Welcome Trust Centre for Cell Biology, Edinburgh, Scotland, UK; 3) Centre for System Biology at Edinburgh (CSBE), University of Edinburgh, Scotland, UK.
80 - 5:45
Stat92E and dMyc act in parallel to promote cellular growth by regulating ribosomal biogenesis. Aloma Rodrigues, Erika Bach. Pharmacology Dept., New York University School of Medicine, NY.
81 - 6:00
Intrinsic tumor suppression by cell competition through TNF-JNK signaling. Tatsushi Igaki1,2, Jose Carlos Pastor-Pareja2, Hiroka Aonuma3, Masayuki Miura3, Tian Xu2. 1) Dept of Cell Biol, Kobe Univ, Kobe, Japan; 2) Dept of Genetics/HHMI, Yale Univ, New Haven, CT; 3) Dept of Genetics, Univ of Tokyo, Tokyo, Japan.
82 - 6:15
Identification of Novel Regulators of Cell Competition. Yassi Hafezi, Iswar Hariharan. Dept Molecular & Cell Biol, Univ California, Berkeley, Berkeley, CA.
Friday, March 6 4:30 PM–6:30 PM
Chicago 8-10
RNA Biology
Moderator: Andrew Simmonds, University of Alberta, Edmonton, Canada
Room: Chicago 8-10
83 - 4:30
A comprehensive analysis of germ layer-specific miRNA expression in the early fly embryo. Benjamin Haley, David Hendrix, Michael Levine. UC Berkeley, Berkeley, CA.
84 - 4:45
Comparative Analysis of Argonaute-dependent Small RNA Pathways in Drosophila. Rui Zhou1,5, Ikuko Hotta2,3,5, Ahmet M. Denli2, Pengyu Hong4, Norbert Perrimon1, Gregory J. Hannon2. 1) Harvard Medical School, Dept. of Genetics, HHMI, Boston, MA; 2) Watson School of Biological Sciences, HHMI, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY; 3) Graduate Program in Molecular and Cellular Biology, State University of New York at Stony Brook, Stony Brook, NY; 4) Dept. of Computer Science, Brandeis University, Waltham, MA; 5) Equal contribution.
85 - 5:00
Division of labor between two dsRNA binding proteins in RNAi. Joao T. Marques, Kevin Kim, Pei-Hsuan Wu, Richard Carthew. BMBCB, Northwestern University, Evanston, IL.
86 - 5:15
Drosophila endogenous small silencing RNAs: Biogenesis to Action. Megha Ghildiyal1, Hervé Seitz1, Phillip Zamore1,2. 1) Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605; 2) Howard Hughes Medical Institute.
87 - 5:30
Drosophila Fragile X Protein controls cellular proliferation by regulating cbl levels in the ovary. Daniela C. Zarnescu, Andrew Epstein, Christopher Bauer, Aaron Ho, Giovanni Bosco. Dept Molecular & Cell Biol, Univ Arizona, Tucson, AZ.
88 - 5:45
eyes absent and sine oculis transcripts are bound and positively regulated by RISC. Justin P. Kumar, Arthur Luhur. Dept Biol, Indiana Univ, Bloomington, IN.
89 - 6:00
Novel roles for two RNA binding proteins of the Bic-D RNA transport machinery: poly-A independent role for PABP in osk mRNA localization and control of protein levels by IMP. P. Vazquez Pianzola1, S. L. Bullock2, H. Urlaub3, B. Suter1. 1) Institute of Cell Biology, University of Bern, Bern, Switzerland; 2) Medical Research Council Laboratory of Molecular Biology, Division of Cell Biology, Cambridge, United Kingdom; 3) Bioanalytical Mass Spectrometry Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
90 - 6:15
Two modes of translational repression by the nanos 3'UTR. Shane Andrews, Elizabeth Gavis. Dept Molecular Biol, Princeton Univ, Princeton, NJ.
Saturday, March 7 8:30 AM–10:15 AM
Sheraton 4/5
Cell Biology and Signal Transduction
Moderator: Henry Chang, Purdue University, West Lafayette, Indiana
Room: Sheraton 4/5
91 - 8:30
Bicaudal-C Associates with a Trailer Hitch Complex and is Required for Efficient Gurken Secretion. Jan-Michael Kugler1,3, Jarred Chicoine2,3, Paul Lasko1. 1) Dept. of Biology, McGill University, Montreal, QC, Canada; 2) Dept. of Human Genetics, McGill University and Genome Quebec Innovation Centre, Montreal, QC, Canada; 3) equal contribution.
92 - 8:45
Spatial and temporal control of border cell migration requires integration of cytokine and steroid hormone signals mediated by the BTB protein Abrupt. Anna C.-C. Jang1, Yu-Chiuan Chang1, Jianwu Bai2, Denise Montell1. 1) Dept Biological Chemistry, JHMI, Rangos, Room 440 , Baltimore, MD; 2) Department of Genetics, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA.
93 - 9:00
gon-1 is an ADAMTS required for proper cell migration during embryogenesis. Afshan Ismat, Alan Cheshire, Deborah Andrew. Dept Cell Biol, Johns Hopkins Sch Med, Baltimore, MD.
94 - 9:15
Hierarchical organization of Hedgehog and its significance. Neha Vyas1,2, Debanjan Goswami1, Pranav Sharma1,4, H. A. Ranganath2, K. Vijay Raghavan1, L. S. Shashidhara3, R. Sowdhamini1, Satyajit Mayor1. 1) National Centre for Biological Sciences, Bangalore, Karnataka, India; 2) Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysore, India; 3) Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad, India 500 007; 4) Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
95 - 9:30
G protein Gai functions immediately downstream of Smoothened in Hedgehog Signaling. Stacey K. Ogden1,2, Dennis Liang Fei2, Neal S. Schilling2, Yashi F. Ahmed3,4, John Hwa2, David J. Robbins2,4. 1) Dept Molecular Pharm, St Jude Children's Research Hospital, Memphis, TN; 2) Dept Pharm/Tox, Dartmouth Med Sch, Hanover, NH; 3) Dept Genetics, Dartmouth Med Sch, Hanover, NH; 4) Norris Cotton Cancer Center, Lebanon, NH.
96 - 9:45
Role and control of Patched traffic in Hedgehog signalization. Amira Brigui, Anne Plessis. Institut Jacques Monod, CNRS, Paris, France.
97 - 10:00
Genetic and biochemical definition of Drosophila Hedgehog receptor. Xiaoyan Zheng1, Philip Beachy1,2. 1) Dev.Bio, Stanford University, Stanford, CA; 2) HHMI.
Saturday, March 7 8:30 AM–10:15 AM
Chicago 6/7
Physiology and Aging
Co-Moderators: Rolf Bodmer, Burnham Institute, La Jolla, California and Eric Rulifson, University of California, San Diego, California
Room: Chicago 6/7
98 - 8:30
Positive and negative effects on lifespan and viability of perturbation of glutathione titres in Drosophila melanogaster. Claire Kotecki, Robert D. C. Saunders. Life Sciences, Open University, Milton Keynes, Buckinghamshire, United Kingdom.
99 - 8:45
Regulation of Lipid Homeostasis by the Drosophila DHR96 Nuclear Receptor. Matt Sieber, Carl Thummel. Dept Human Genetics, Univ Utah, Salt Lake City, UT.
100 - 9:00
AMPK promotes growth in Drosophila by regulating nutrient intake and muscle activity in the gut. Michelle L. Bland, Morris J. Birnbaum. Dept Medicine, Rm CRB 315A, Univ Pennsylvania, Philadelphia, PA.
101 - 9:15
Size Matters: FOXO regulates the relationship between organ size and body size in Drosophila. Alexander Shingleton1, Huiyuan Tang1, Martha Caldas2. 1) Department of Zoology, Michigan State University, East Lansing, MI; 2) Division of Biology, Kansas State University, Manhattan, KS.
102 - 9:30
Anatgonistic and nutrient dependent effects on lifespan upon tissue specific modulation of mitochondrial function in Drosophila melanogaster. Subhash Katewa, Miguel Vargas, Pankaj Kapahi. Buck institute of Age Research, Novato, CA.
103 - 9:45
Exercise-training delays age-related decline in cardiac function and mobility through a mitochondrial-dependent mechanism. Nicole M. Piazza1, Robert Arking2, Robert Wessells1. 1) Univ Michigan, Ann Arbor, MI; 2) Wayne State University, Detroit, MI.
104 - 10:00
The Drosophila adult epidermis - a model system to study tissue aging. Christoph Scherfer, Michael Galko. Dpt. of Biochemistry & Molecular Biology, M D Anderson Cancer Center, Houston, TX 77030, USA.
Saturday, March 7 8:30 AM–10:15 AM
Chicago 8-10
Immunity and Pathogenesis
Co-Moderators: Louisa Wu, University of Maryland, College Park and Kurt McKean, University at Albany, New York
Room: Chicago 8-10
105 - 8:30
Functional dissection of phagocytosis in the immune system and in nervous system development. Sofia Axelrod, Estee Kurant, Ulrike Gaul. Developmental Neurogenetics, Rockefeller University, New York, NY.
106 - 8:45
Specific aspects of immunity are circadian regulated in Drosophila. Michele Mie Shirasu-Hiza, David Schneider. Microbiology & Immunology, Stanford Univ, Stanford, CA.
107 - 9:00
Signal-induced IMD cleavage, DIAP2 association and polyubiquitination drives innate immune signaling in Drosophila. Nicholas Paquette1, Meike Broemer2, Deniz Erturk-Hasdemir1, Kamna Aggarwal1, Jean-Marc Reichhart3, Pascal Meier2, Neal Silverman1. 1) Div. of Infectious Disease, Dept. Medicine, Univ. of Massachusetts Medical School, Worcester; 2) Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research, London, UK; 3) Institut de Biologie Moléculaire et Cellulaire, CNRS, Strasbourg, France.
108 - 9:15
TGF-b signalling in immunity: why first impressions are deadly. Rebecca Clark, Marc Dionne. Craniofacial development, King's College London, London, SE1 9RT, United Kingdom.
109 - 9:30
Identification of an innate immune factor that modulates Rift Valley Fever virus infection in Drosophila. Sheri L. Hanna, Shelly Bambina, Sara Cherry. Dept of Microbiology & Penn Genomic Frontiers Inst, Univ of Pennsylvania, Philadelphia, PA.
110 - 9:45
Microbial diversity associated with natural Drosophila populations. James Angus Chandler, Jenna L. Morgan, Jonathan A. Eisen, Artyom Kopp. Center for Population Biology, University of California-Davis, Davis, CA.
111 - 10:00
Homeostasis of the Drosophila intestinal epithelium during Serratia marcescens oral infections. Dominique X. Ferrandon1, Samuel Liégeois1, Stefanie Limmer1, Richard Bou Aoun1, Nadine Nehme1,2, Shane Cronin2, Ingo Ebersberger2, Josef Penninger2, Philippe Gianmmarinaro1, Arshad Ayyaz1. 1) IBMC, CNRS UPR 9022, Equipe FRM Strasbourg, France; 2) IMBA, Vienna, Austria.
Saturday, March 7 10:45 AM–12:30 PM
Sheraton 4/5
Cell Biology and Signal Transduction
Moderator: Henry Chang, Purdue University, West Lafayette, Indiana
Room: Sheraton 4/5
112 - 10:45
Reversible mono-ubiquitination at a conserved Lysine in Medea/Smad4 regulates TGFbeta signaling. Stuart J. Newfeld1, Robert G. Wisotzkey2, Sirio Dupont3, Stefano Piccolo3. 1) School of Life Sciences, Arizona State Univ, Tempe, AZ; 2) Dept. of Biological Sciences, California State University - East Bay, Hayward, CA; 3) Department of Medical Biotechnologies, University of Padova, Padova, Italy.
113 - 11:00
crossveinless d encodes a vitellogenin domain lipoprotein required for normal BMP signaling during the formation of the posterior crossvein. Jun Chen1,2, Seth Blair1. 1) Zoology, UW-Madison, Madison, WI; 2) Genetics, UW-Madison, Madison, WI.
114 - 11:15
The Sanpodo NPAF motif controls Numb binding and endocytosis but not Notch signaling regulation. Fabrice Roegiers, Diana Zitserman, Ilya Serebriiskii, Mark Andrake, Roland Dunbrack, Xin Tong. Inst Cancer Research, Fox Chase Cancer Ctr, Philadelphia, PA.
115 - 11:30
Decoding the Notch signal: genome-wide analysis of direct targets of Notch activation. Sarah Bray, Alena Krejci, Fred Bernard, Ben Housden, Steph Collins. PDN, Univ Cambridge, Cambridge, United Kingdom.
116 - 11:45
Similar to Notch: Characterization of the role of Sima/Hif-1a in lineage specification during Drosophila larval hematopoiesis. T. Mukherjee, W. Kim, U. Banerjee. Dept. of Molecular Cell and Developmental Biology, University of California, Los Angeles.
117 - 12:00
Towards an Understanding of the Prothoracicotropic Hormone Signal Transduction Pathway. Kim F. Rewitz1, Martin R. Larsen2, Lawrence I. Gilbert3, Michael B. O'Connor1. 1) Dept. of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN; 2) Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense, Denmark; 3) Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280.
118 - 12:15
The role of the novel F-box protein Nutcracker at the intersection of caspase activation and proteasome activity. Maya Bader1, Hermann Steller1,2. 1) The Rockefeller University, New York, NY; 2) Howard Hughes Medical Institute.
Saturday, March 7 10:45 AM–12:30 PM
Chicago 6/7
Neurogenetics and Neural Development
Moderator: Dietmar Schmucker, Harvard Medical School, Boston, Massachusetts
Room: Chicago 6/7
119 - 10:45
Mechanisms specifying dendritic morphogenesis in an identified neuron in the Drosophila olfactory system. Ajeet Pratap Singh1, K. Vijay Raghavan2, Veronica Rodrigues1,2. 1) Dept of Biological Sciences, TIFR, Mumbai, India; 2) National Centre for Biological Sciences, TIFR, GKVK, Bangalore, India.
120 - 11:00
dfezl encodes a novel regulator that restricts stem cell potential in transit amplifying cells in Drosophila. M. Weng1,2, K. Golden1,2, C. Gamble2, C.-Y. Lee1,2. 1) Cell & Dev Biol, Univ Michigan; 2) Center for Stem Cell Biology, Life Sci Inst, Univ Michigan, Ann Arbor, MI.
121 - 11:15
The cAMP effector PKA acts downstream of the GPCR Moody in glial blood-brain barrier development. Xiaoling Li, Ulrike Gaul. Laboratory of Developmental Neurogenetics, Rockefeller University, 1230 York Ave, New York, NY 10021.
122 - 11:30
distal-less regulates Drosophila olfactory system development. Grace Boekhoff-Falk1,2, Jessica Plavicki1,2. 1) Dept. of Anatomy, University of Wisconsin, Madison; 2) Neuroscience Training Program, University of Wisconsin, Madison.
123 - 11:45
Rhodopsin 6 protein maintains transcriptional repression of rhodopsin 5 in R8 photoreceptors. Daniel Vasiliauskas1, Esteban Mazzoni2, Claude Desplan1. 1) Department of Biology, New York University, New York, NY; 2) Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY.
124 - 12:00
Over-Expression of Abelson Tyrosine Kinase in a frazzled mutant inhibits commissure formation. Mark VanBerkum1, Joy Dorsten1, Stephanie Karmo1, Mark Seeger2. 1) Biological Sciences, Wayne State University, Detroit, MI; 2) Molecular Genetics and the Neurobiotechnology Center, The Ohio State University, Columbus, OH.
125 - 12:15
Regulation of postsynaptic development by Activin/TGF-b signaling pathway in Drosophila larval neuromuscular junction. Myung-Jun Kim1,2, Yi Ren1, Michael B. O'Connor1,2. 1) Department of Genetics, Cell Biology and Development; 2) Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Saturday, March 7 10:45 AM–12:30 PM
Chicago 8-10
Cell Cycle, Checkpoints and Cell Death
Co-Moderators: Mary Lilly, National Institutes of Health, Bethesda, Maryland and Jamie Rusconi, University at Albany, New York
Room: Chicago 8-10
126 - 10:45
Effector caspase Dcp-1 and IAP protein Bruce regulate starvation-induced autophagy during Drosophila oogenesis. S. Gorski1,2, S. Chittaranjan1, S. Gonzalez Barbosa3, L. DeVorkin1,2, K. McCall3, C. Hou1. 1) Genome Sciences Centre, British Columbia Cancer Research Centre, Vancouver, BC, Canada; 2) Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada; 3) Department of Biology, Boston University, Boston MA, USA.
127 - 11:00
Novel Genes Required for Communal Cell Death. Nichole Link, Po Chen, Wan-Jin Lu, John M. Abrams. Cell Biology, UT Southwestern Medical Center, Dallas, TX.
128 - 11:15
The role of Drosophila p53 and damage induced apoptosis in genomic stability. Sarah R. Oikemus, Laura McNamee, Michael Brodsky. Dept PGF&E, Univ Massachusetts, Worcester, MA.
129 - 11:30
Cyclin C is required for the appropriate execution of cell death in Drosophila. Dongbin Xu, Zhihong Chen, Andreas Bergmann. Dept Biochem & Molec Biol, Univ Texas MD Anderson CA Ctr, Houston, TX.
130 - 11:45
Cell cycle progression and timing in the early embryo. Mark McCleland, Jeffrey Farrell, Patrick O'Farrell. Biochemistry and Biophysics, University of California, San Francisco.
131 - 12:00
SOLO: A Novel Meiotic Cohesion Protein in Drosophila melanogaster. R. Yan, S. Thomas, J. Miller, J. Tsai, B. McKee. Department of Biochemistry, Cellular and Molecular Biology, University of Tennessee 1414 Cumberland Ave, Knoxville, TN 37996.
132 - 12:15
The functional analysis of Drosophila ORC6. Igor N. Chesnokov, Maxim Balasov, Richard Huijbregts, Anton Svitin. Dept Biochem & Molecular Gen, Univ. of Alabama, Birmingham.
Saturday, March 7 4:00 PM–6:00 PM
Sheraton 4/5
Pattern Formation
Moderator: Chip Ferguson, University of Chicago, Illinois
Room: Sheraton 4/5
133 - 4:00
Spatial bistability plays a central role in the threshold-dependent reading mechanism of Bicoid positional information in Drosophila. F. Lopes1,5, F. Vieira2, D. Holloway3,4, A. Spirov5, P. Bisch1. 1) Biophysics Institute, UFRJ, Rio de Janeiro, Brazil; 2) Instituto de Quimica, UnB, Brasilia, Brazil; 3) Mathematics Department, BCIT, Burnaby, Canada; 4) Biology Department, UV, Victoria, Canada; 5) Department of Applied Mathematics, SUNYSB, Stony Brook, USA.
134 - 4:15
Evidence for a composite anterior determinant in the hover fly Episyrphus balteatus (Syrphidae), a cyclorrhaphan fly with an anterodorsal serosa anlage. Steffen Lemke, Urs Schmidt-Ott. Department of Organismal Biology & Anatomy, University of Chicago, Chicago, IL.
135 - 4:30
Comparative analysis of gene expression patterns reveals putative gene functions of previously undescribed genes. Erwin Frise, Richard Weiszmann, Ann Hammonds, Susan Celniker. BDGP, Lawrence Berkeley Nat Lab, Berkeley, CA.
136 - 4:45
A combinatorial code for pattern formation in Drosophila oogenesis. N. Yakoby1,2,3, C. A. Bristow2,3, J. Lembong2,3, J. J. Zartman2,3, M. S. Halfon4, T. Schüpbach5, S. Y. Shvartsman2,3, NY and CAB are equal contributors. 1) Dept Biol, Rutgers Univ, Camden, NJ; 2) Lewis-Sigler Institute for Integrative Genomics, Princeton Univ, Princeton, NJ; 3) Dept Chem Eng, Princeton Univ, Princeton, NJ; 4) Dept Biochem, SUNY, Buffalo, NY; 5) HHMI and Dept Mol Biol, Princeton Univ, Princeton, NJ.
137 - 5:00
Actomyosin Contractility and Junctional Conversions are Required for Cell Row Alignment in the Drosophila Embryo. Robert Simone, Stephen DiNardo. Dept Cell & Dev Biol, Univ Pennsylvania, Philadelphia, PA.
138 - 5:15
Dynamic interpretation of the Hedgehog morphogen gradient in the Drosophila wing disc. Angelike Stathopoulos1, Marcos Nahmad1,2. 1) Div Biol, MC 114-96, Caltech, Pasadena, CA; 2) Dept of Control & Dynamical Systems, Caltech, Pasadena, CA.
139 - 5:30
Regenerative growth in Drosophila imaginal discs is regulated by Wg and Myc. Rachel K. Smith-Bolton, Melanie Worley, Hiroshi Kanda, Iswar K. Hariharan. Molec & Cell Biol, Univ California, Berkeley, Berkeley, CA.
140 - 5:45
Fate Specification in Systems of Autonomously Bistable Cells Interacting via an Inhibitory Signal. Matthew W. Pennington1, David K. Lubensky2, Nick E. Baker3. 1) Biophysics, University of Michigan, Ann Arbor, MI; 2) Physics, University of Michigan, Ann Arbor, MI; 3) Molecular Genetics and Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, NY.
Saturday, March 7 4:00 PM–6:00 PM
Chicago 6/7
Stem Cells
Moderator: Haifan Lin, Yale University School of Medicine, New Haven, Connecticut
Room: Chicago 6/7
141 - 4:00
Analysis of adult epithelial sheath muscle cell proliferation. Akemi J. Tanaka, Lynn Cooley. Department of Genetics, Yale University School of Medicine, New Haven, CT.
142 - 4:15
Ecdysone regulates female germline stem cell division and self-renewal. Elizabeth T. Ables, Daniela Drummond-Barbosa. Department of Cell & Developmental Biology, Vanderbilt University Medical Center, Nashville, TN.
143 - 4:30
A novel checkpoint mechanism monitors centrosome orientation in Drosophila male germline stem cells. Hebao Yuan, Yukiko M. Yamashita. Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Ann Arbor.
144 - 4:45
Notch signaling together with bowl contribute to the establishment of the testis stem cell-niche system. Tishina Okegbe1,2, Natalie Terry1, Sarah Freilich1,2, Tim Kelliher1, Stephen DiNardo1,2. 1) Cell & Developmental Biology, University of Pennsylvania, School of Medicine, Philadelphia, PA; 2) The Institute for Regenerative Medicine, University of Pennsylvania, Philadelphia, PA.
145 - 5:00
The chromatin-remodeling factor NURF maintains stem cells in the Drosophila testis by regulating the JAK/STAT signaling pathway. Christopher Cherry, Erika Matunis. Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD.
146 - 5:15
Testing the functional consequences of adaptive protein evolution at the Drosophila germline stem cell regulatory gene bag of marbles. Heather A. Flores, Daniel A. Barbash, Charles F. Aquadro. Dept. of Molecular Biology and Genetics, Cornell University, Ithaca, NY.
147 - 5:30
Molecular Determinants of Drosophila Hematopoietic Precursors in Lymph Gland Development. Lolitika Mandal1, Julian A. Martinez-Agosto2, Utpal Banerjee1. 1) Dept MCD Biol, Univ California, Los Angeles, Los Angeles, CA; 2) Department of Human Genetics and Division of Medical Genetics of the department of Pediatrics, David Geffen School of Medicine at UCLA.
148 - 5:45
Tissue damage-induced intestinal stem cell division in Drosophila. Alla Amcheslavsky1, Jin Jiang4, Tony Ip1,2,3. 1) Program in Molecular Medicine; 2) Program in Cell Dinamics, and; 3) Program in Cell Biology, UMASS Medical School, Worcester, MA,01605; 4) Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390.
Saturday, March 7 4:00 PM–6:00 PM
Chicago 8-10
Techniques and Functional Genomics
Moderator: Mike Eisen, Howard Hughes Medical Institute, University of California, Berkeley
Room: Chicago 8-10
149 - 4:00
Molecularly defined 80 kb duplications for the X-chromosome. Thom Kaufman1, Koen J. T. Venken2, Ellen Popodi1, Joseph W. Carlson4, Karen L. Schulze2,3, Stacy Holtzman1, Dave Miller1, Roger A. Hoskins4, Hugo J. Bellen2,3. 1) Dept Biol, Indiana Univ, Bloomington, IN; 2) Program in Developmental Biology, Dept of Molecular & Human Genetics, BCM, Houston, TX; 3) HHMI; 4) Dept of Genome & Computational Biology, LBNL, Berkeley, CA.
150 - 4:15
Expanding the coverage and versatility of the Gene Disruption Project collection. Hugo J. Bellen1,2, Robert W. Levis3, Koen J. T. Venken1, Yuchun He1,2, Joseph W. Carlson4, Martha Evans-Holm4, Karen L. Schulze1,2, Roger A. Hoskins4, Allan C. Spradling2,3. 1) Molecular & Human Genetics, BCM, Houston, TX; 2) HHMI; 3) Dept Embryology, Carnegie Inst of Washington, Baltimore, MD; 4) Dept Genome & Comput Biology, LBNL, Berkeley, CA.
151 - 4:30
In vivo luciferase screening leaves GFP in the dark. Julio Cho1,3, Michele Markstein1,3, Norbert Perrimon1,2. 1) Genetics, Harvard Medical School, Boston, MA; 2) HHMI, Harvard Medical School, Boston, MA; 3) Contributed equally.
152 - 4:45
Expanded recombineering toolkit for cross species genome manipulation. Radoslaw K. Ejsmont, Pavel Tomancak. Tomancak Lab, MPI-CBG, Dresden, Germany.
153 - 5:00
A library of site-directed RNAi transgenes for conditional gene inactivation in Drosophila. Krystyna M. Keleman1,2, Georg Dietzl1,2, Silvia Oppel1,2, Michaela Fellner1,2, Thomas Horn3, Thomas Micheler1,2, Michael Boutros3, Barry J. Dickson1. 1) IMP, Vienna, Austria; 2) VDRC, Vienna, Austria; 3) DKFZ, Heidelberg, Germany.
154 - 5:15
A high resolution map of the transcriptome by deep RNA sequencing. Bryce Daines1, Hui Wang2, Henry Song2, Wei Li3, Rui Chen1,2. 1) Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; 2) Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX; 3) Mollecular and Cellular Biology, Baylor College of Medicine, Houston, TX.
155 - 5:30
Creation of an in vivo UAS-cDNA library to study growth regulation in Drosophila. Claus Schertel, Johannes Bischof, Edy Furger, Konrad Basler. Institute of Molecular Biology, University of Zurich, Zurich, Switzerland.
156 - 5:45
Computational analysis of the Dorsal morphogen gradient. Jitendra S. Kanodia1, Yoosik Kim1, Robert DeLotto3, Jennifer Lippincott-Schwartz2, Stanislav Y. Shvartsman1. 1) Department of Chemical Engineering and Lewis Sigler Institute of Integrative Genomics, Princeton University, Princeton, NJ; 2) Cell Biology and Metabolism Branch National Institutes of Health, Bethesda, MD; 3) Department of Molecular Biology, University of Copenhagen, Copenhagen N, Denmark.
Sunday, March 8 8:30 AM–12:00 NOON
Sheraton/Chicago Center
Plenary Session II
Moderator: Lynn Cooley, Yale University, New Haven, Connecticut
Room: Sheraton/Chicago Center
Presentations:
8:30 am Poster Award Presentation. John Carlson. Yale University, New Haven, Connecticut.
8:35 am Balancing Tolerance and Resistance During Infections of the Fly. David Schneider. Stanford University, California.
9:00 am Autophagy Regulates Synaptic Growth at the Larval Neuromuscular Junction. Barry Ganetzky. University of Madison, Wisconsin.
9:30 am Battle and Ballet: Interactions Between Male Seminal Proteins and Mated Female Drosophila. Mariana Wolfner. Cornell University, Ithaca, New York.
10:00 am - Break
10:30 am Roles of Organelle Dynamics in Shaping Cells. Tadashi Uemura. Kyoto University, Japan.
11:00 am Stem Cells, Insulin, and the Control of Oogenesis by Diet in the Drosophila. Daniela Drummond-Barbosa. Vanderbilt University Medical Center, Nashville, Tennessee.
11:30 am Structure and Evolution of Centromeric Chromatin. Steve Henikoff. Fred Hutchison Cancer Research Center, Seattle, Washington.
|
